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Search Results for " sonic hedgehog "

Targets Recommended: Hedgehog/Smoothened

7

抑制剂 & 化合物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T22089	HPI 1	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	HPI 1 是一种刺猬 (Hh) 信号抑制剂。在 Shh-LIGHT2 细胞中抑制 Sonic Hedgehog (Shh)-、SAG- 和 Gli 诱导的 Hh 通路激活（Shh-、SAG-、Gli2- 和 Gli1 诱导的激活的 IC50 值为 1.5、1.5、4 和 6 μM） .
T26899	BRD50837 BRD-50837,BRD 50837
	BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).
T26901	BRD-9526 BRD 9526
	BRD-9526 is a potent and selective inhibitor of Sonic Hedgehog (Shh).
T23307	SANT 2 SANT-2	Others	Others
	SANT-2 is an inhibitor of Sonic hedgehog signaling and also antagonizes smoothened receptor activity (KD = 12 nM).
T25918	Palmitoyl-L-aspartic acid L-N-Palmitoylaspartic acid
	Palmitoyl-L-aspartic acid is a natural N-acylaspartate that suppresses Hedgehog signaling after stimulation with Smoothened agonist or non-sterol-modified Sonic Hedgehog. It does not alter the activity of cannabinoid receptors or fatty acid amide hydrolas
T35538	HPI-1 (hydrate) HPI-1 hydrate
	HPI-1 (hydrate) is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Sonic Hh (IC50= 1.5 μM) without significantly affecting Wnt signaling (IC50≥ 30 μM).1HPI-1 suppresses Hh activation induced by loss of Suppressor of Fused or by Gli overexpression, suggesting action at posttranslational modification of Gli protein or at the interaction of Gli with a co-factor.1HPI-1 (hydrate) also inhibits signaling through the oncogenic Smoothened (Smo) mutant SmoM2 in neuron precursors, prev...
T35940	Darinaparsin Dimethylarsinic glutathione,Darinaparsin
	Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC50s = 5-10 &#181M) and patient-derived primary prostate cancer cells (IC50s = 2.5-20 &#181M), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC50s = 2.7 and 1.3 &#181M, respectively). [1][2] It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G2/M phase. Darinaparsin decreases transcription of Gli-2,...

化合物

Cat.No: T22089

Target: Hedgehog/Smoothened

Cat.No: T26899

Synonym: BRD-50837,BRD 50837

Cat.No: T26901

Synonym: BRD 9526

Cat.No: T23307

Synonym: SANT-2

Target: Others

Palmitoyl-L-aspartic acid

Cat.No: T25918

Synonym: L-N-Palmitoylaspartic acid

HPI-1 (hydrate)

Cat.No: T35538

Synonym: HPI-1 hydrate

Cat.No: T35940

Synonym: Dimethylarsinic glutathione,Darinaparsin

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03345	Sonic Hedgehog Protein, Mouse, Recombinant (His) Hhg1,Hxl3,9530036O11Rik,Dsh,Hx,sonic hedgehog	Mouse	HEK293 Cells
	Sonic Hedgehog Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21 kDa and the accession number is Q62226.
TMPJ-01171	SHH Protein, Mouse, Recombinant (C25II) HHG-1,SHH,Sonic Hedgehog Protein	Mouse	E. coli
	SHH Protein, Mouse, Recombinant (C25II) is expressed in E. coli expression system. The predicted molecular weight is 18-20 KDa and the accession number is Q62226.
TMPJ-01170	SHH Protein, Mouse, Recombinant HHG-1,Sonic Hedgehog Protein,SHH	Mouse	E. coli
	SHH Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20 KDa and the accession number is Q62226.
TMPJ-01128	SHH Protein, Human, Recombinant (C24II) HHG-1,Sonic Hedgehog Protein,SHH	Human	E. coli
	SHH Protein, Human, Recombinant (C24II) is expressed in E. coli expression system. The predicted molecular weight is 20 KDa and the accession number is Q15465.
TMPJ-01127	SHH Protein, Human, Recombinant Sonic Hedgehog Protein,SHH,HHG-1	Human	E. coli
	SHH Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19 KDa and the accession number is Q15465.
TMPY-02832	SHH Protein, Human, Recombinant (aa 198-462, His) SMMCI,HLP3,HHG1,TPTPS,HPE3,MCOPCB5,TPT,Sonic he...	Human	HEK293 Cells
	SHH Protein, Human, Recombinant (aa 198-462, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 29 kDa and the accession number is Q15465.
TMPY-02905	SHH Protein, Human, Recombinant (aa 1-197, His) HHG1,MCOPCB5,SMMCI,Sonic hedgehog,TPTPS,HP...	Human	HEK293 Cells
	SHH Protein, Human, Recombinant (aa 1-197, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 21 kDa and the accession number is Q15465.
TMPY-02384	MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP) metastasis suppressor 1,MIMB,MIM,MIMA	Human	E. coli
	MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor...

重组蛋白

Sonic Hedgehog Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03345

Species: Mouse

Expression System: HEK293 Cells

SHH Protein, Mouse, Recombinant (C25II)

Cat.No: TMPJ-01171

Species: Mouse

Expression System: E. coli

SHH Protein, Mouse, Recombinant

Cat.No: TMPJ-01170

Species: Mouse

Expression System: E. coli

SHH Protein, Human, Recombinant (C24II)

Cat.No: TMPJ-01128

Species: Human

Expression System: E. coli

SHH Protein, Human, Recombinant

Cat.No: TMPJ-01127

Species: Human

Expression System: E. coli

SHH Protein, Human, Recombinant (aa 198-462, His)

Cat.No: TMPY-02832

Species: Human

Expression System: HEK293 Cells

SHH Protein, Human, Recombinant (aa 1-197, His)

Cat.No: TMPY-02905

Species: Human

Expression System: HEK293 Cells

MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP)

Cat.No: TMPY-02384

Species: Human

Expression System: E. coli

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